Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077966 | 0.77 | KDM4E (0.53) | ALDH1A1SIGMAR1DRD4 | |
| SCHEMBL3306841 | 0.75 | SIGMAR1 (0.68) | CYP2C19SMN1; SMN2ALDH1A1SIGMAR1DPP7 | |
| SCHEMBL18658213 | 0.74 | SIGMAR1 (0.61) | CYP2C19SMN1; SMN2ALDH1A1SIGMAR1DPP7 | |
| SCHEMBL17301746 | 0.73 | SIGMAR1 (0.60) | ALDH1A1SIGMAR1DRD2POLBDRD4 | |
| SCHEMBL7381847 | 0.73 | LMNA (0.63) | LMNA | |
| SCHEMBL7501907 | 0.73 | ABL1 (0.54) | SIGMAR1KMT2A | |
| SCHEMBL5083782 | 0.73 | ATM (0.55) | SIGMAR1KMT2A | |
| SCHEMBL6419381 | 0.73 | USP2 (0.50) | CYP2C19LMNAALDH1A1KMT2A | |
| SCHEMBL4848461 | 0.73 | SIGMAR1 (0.65) | CYP2C19SMN1; SMN2ALDH1A1SIGMAR1DPP7 | |
| SCHEMBL17294721 | 0.73 | SIGMAR1 (0.65) | CYP2C19ALDH1A1SIGMAR1DPP7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368314-A1 | N-4-PIPERIDINYL COMPOUNDS AS CCR5 MODULATORS | AstraZeneca AB (SE) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070479-A1 | N-4-PIPERIDINYL COMPOUNDS AS CCR5 MODULATORS | ASTRAZENECA AB (SE) | 2002-09-12 | — | — | WO | disclosed |