Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13396905 | 0.92 | BACE1 (0.63) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL4848461 | 0.89 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL29712058 | 0.89 | SIGMAR1 (0.65) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL14116101 | 0.88 | SIGMAR1 (0.63) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2 | |
| Benzene SCHEMBL10799860 | 0.87 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL6207514 | 0.85 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL4846139 | 0.85 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL4846164 | 0.85 | SIGMAR1 (0.60) | SIGMAR1ALDH1A1CYP2C19SMN1; SMN2DRD4 | |
| SCHEMBL25139432 | 0.84 | ALDH1A1 (0.62) | ALDH1A1CYP2C19DRD4DRD2DRD3 | |
| SCHEMBL3164487 | 0.84 | SIGMAR1 (0.74) | SIGMAR1CYP2C19DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101796027-A | N-piperidin-4-ylmethyl-amide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH AS | 2010-08-04 | — | — | CN | claimed |
| US-10167299-B2 | 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-01-01 | — | — | US | disclosed |
| US-20170129916-A1 | NOVEL BETULINIC PROLINE IMIDAZOLE DERIVATIVES AS HIV INHIBITORS | HETERO RESEARCH FOUNDATION (IN) | 2017-05-11 | — | — | US | disclosed |
| US-20170129916-A1 | NOVEL BETULINIC PROLINE IMIDAZOLE DERIVATIVES AS HIV INHIBITORS | HETERO RESEARCH FOUNDATION (IN) | 2017-05-11 | — | — | US | disclosed |
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-02-16 | — | — | US | disclosed |
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-02-16 | — | — | US | disclosed |
| US-20140065070-A1 | METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS | MCMASTER UNIVERSITY (CA) | 2014-03-06 | — | — | US | disclosed |
| CN-101796027-A | N-piperidin-4-ylmethyl-amide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH AS | 2010-08-04 | — | — | CN | disclosed |
| US-20100093795-A1 | Piperidine Derivative Used for Treating Chemokine Receptor 5 Mediated Diseases | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| US-20100093795-A1 | Piperidine Derivative Used for Treating Chemokine Receptor 5 Mediated Diseases | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| US-7294636-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-11-13 | — | — | US | disclosed |
| US-20070167442-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-19 | — | — | US | disclosed |
| WO-2007066201-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007066201-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2007-06-14 | — | — | WO | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
| US-20070015788-A1 | N-(3-Aryl-3-substitutedphenylpropyl) piperidines or 8-azabicyclo[3.2.1]octanes that are additionally substituted with an optionally fused 5-member N-heterocycle; the compounds are modulators of CCR5 receptor activity and are used in treating diseases such as rheumatoid arthritis | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | US | disclosed |
| EP-1742934-A2 | PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | AstraZeneca AB (SE) | 2007-01-17 | — | — | EP | disclosed |
| EP-1625120-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005101989-A2 | PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5 | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | WO | disclosed |
| WO-2004099178-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015788-A1 | N-(3-Aryl-3-substitutedphenylpropyl) piperidines or 8-azabicyclo[3.2.1]octanes that are additionally substituted with an optionally fused 5-member N-heterocycle; the compounds are modulators of CCR5 receptor activity and are used in treating diseases such as rheumatoid arthritis | CCR5, CCR2, CX3CR1 | SIGMAR1 670/4885ALDH1A1 531/4885CYP2C19 619/4885 |
| US-20100093795-A1 | Piperidine Derivative Used for Treating Chemokine Receptor 5 Mediated Diseases | CCR5, CCL5, CXCR5 | SIGMAR1 625/4885ALDH1A1 889/4885CYP2C19 3348/4885 |
| US-20170129916-A1 | NOVEL BETULINIC PROLINE IMIDAZOLE DERIVATIVES AS HIV INHIBITORS | BET1, PRR12, PREP | SIGMAR1 4650/4885ALDH1A1 4180/4885CYP2C19 2969/4885 |
| US-20140065070-A1 | METHODS OF PREPARING TRIAZOLE-CONTAINING RADIOIODINATED COMPOUNDS | CYP11B1, CYP11B2, PAICS | SIGMAR1 1461/4885ALDH1A1 645/4885CYP2C19 178/4885 |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | SIGMAR1 2342/4885ALDH1A1 1079/4885CYP2C19 3141/4885 |
| US-20070167442-A1 | Chemical compounds | CCR5, CXCR3, CX3CR1 | SIGMAR1 442/4885ALDH1A1 586/4885CYP2C19 337/4885 |
| US-20170044187-A1 | 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | CCR5, CCR1, CCRL2 | SIGMAR1 928/4885ALDH1A1 297/4885CYP2C19 807/4885 |
| US-10167299-B2 | 1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof | CCR5, CCRL2, CCR1 | SIGMAR1 1086/4885ALDH1A1 823/4885CYP2C19 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.