Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.59 |
| ▸ | MMP13 | P45452 | 14/20 | 0.59 |
| ▸ | MMP9 | P14780 | 9/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | MMP3 | P08254 | 4/20 | 0.47 |
| ▸ | MMP8 | P22894 | 4/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.44 |
| ▸ | MMP7 | P09237 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000066 | 1.00 | MMP1 (0.59) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6996411 | 0.93 | MMP1 (0.61) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6996412 | 0.93 | MMP1 (0.61) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6862104 | 0.91 | MMP1 (0.73) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL7003643 | 0.91 | MMP1 (0.73) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6998238 | 0.90 | MMP1 (0.54) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6998236 | 0.90 | MMP1 (0.54) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL7330071 | 0.87 | MMP1 (0.59) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6818064 | 0.84 | MMP1 (0.78) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL6695057 | 0.84 | MMP1 (0.81) | MMP1MMP13MMP9MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070069-B1 | BICYCLIC HYDROXAMIC ACID DERIVATIVES | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6110964-A | FOR TREATING ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, EMPHYSEMA, ACUTE RESPIRATORY DISTRESS SYNDROME, ASTHMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ALZHEIMER'S DISEASE, ORGAN TRANSPLANT TOXICITY, CACHEXIA, CANCER | PFIZER INC. (US) | 2000-08-29 | — | — | US | disclosed |