Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.61 |
| ▸ | MMP13 | P45452 | 11/20 | 0.48 |
| ▸ | MMP2 | P08253 | 9/20 | 0.48 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP8 | P22894 | 6/20 | 0.48 |
| ▸ | MMP3 | P08254 | 5/20 | 0.48 |
| ▸ | MMP14 | P50281 | 6/20 | 0.45 |
| ▸ | MMP16 | P51512 | 2/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996411 | 1.00 | MMP1 (0.61) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7000070 | 0.93 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6862104 | 0.93 | MMP1 (0.73) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7000066 | 0.93 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7003643 | 0.93 | MMP1 (0.73) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6699509 | 0.84 | MMP1 (0.84) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6876444 | 0.84 | MMP1 (0.81) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6873149 | 0.83 | MMP1 (0.70) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7140679 | 0.83 | MMP1 (0.55) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6992588 | 0.82 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070069-B1 | BICYCLIC HYDROXAMIC ACID DERIVATIVES | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6110964-A | FOR TREATING ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, EMPHYSEMA, ACUTE RESPIRATORY DISTRESS SYNDROME, ASTHMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ALZHEIMER'S DISEASE, ORGAN TRANSPLANT TOXICITY, CACHEXIA, CANCER | PFIZER INC. (US) | 2000-08-29 | — | — | US | disclosed |