Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.73 |
| ▸ | MMP13 | P45452 | 14/20 | 0.59 |
| ▸ | MMP2 | P08253 | 5/20 | 0.59 |
| ▸ | MMP9 | P14780 | 5/20 | 0.59 |
| ▸ | MMP8 | P22894 | 4/20 | 0.59 |
| ▸ | MMP3 | P08254 | 4/20 | 0.59 |
| ▸ | MMP14 | P50281 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862104 | 1.00 | MMP1 (0.73) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6996412 | 0.93 | MMP1 (0.61) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6996411 | 0.93 | MMP1 (0.61) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7000066 | 0.91 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7000070 | 0.91 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6870777 | 0.90 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL6992588 | 0.90 | MMP1 (0.59) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7143794 | 0.87 | MMP1 (0.73) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL7003568 | 0.85 | MMP1 (0.64) | MMP1MMP13MMP2MMP9MMP8 | |
| SCHEMBL25130 | 0.84 | MMP1 (0.96) | MMP1MMP13MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070069-B1 | BICYCLIC HYDROXAMIC ACID DERIVATIVES | PFIZER PROD INC (US) | 2003-07-16 | — | — | EP | disclosed |
| US-6110964-A | FOR TREATING ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, EMPHYSEMA, ACUTE RESPIRATORY DISTRESS SYNDROME, ASTHMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ALZHEIMER'S DISEASE, ORGAN TRANSPLANT TOXICITY, CACHEXIA, CANCER | PFIZER INC. (US) | 2000-08-29 | — | — | US | disclosed |