Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911330 | 0.82 | ALDH1A1 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL6690449 | 0.81 | SMN1; SMN2 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL7005474 | 0.77 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2NPSR1MAPT | |
| SCHEMBL21625506 | 0.75 | PKM (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL6999112 | 0.75 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2NPSR1MAPT | |
| SCHEMBL3391121 | 0.74 | NPSR1 (0.39) | KMT2ASMN1; SMN2ALDH1A1NPSR1MAPT | |
| SCHEMBL7001014 | 0.74 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL7001018 | 0.74 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2NPSR1MAPT | |
| SCHEMBL6997732 | 0.74 | SMN1; SMN2 (0.56) | MEN1KMT2ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL7003999 | 0.71 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |