Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | FNTA | P49354 | 7/20 | 0.44 |
| ▸ | FNTB | P49356 | 7/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | PTAFR | P25105 | 4/20 | 0.42 |
| ▸ | SLC6A15 | Q9H2J7 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002677 | 0.75 | LMNA (0.43) | LMNASMN1; SMN2 | |
| SCHEMBL3839936 | 0.75 | HRH1 (0.60) | LMNAFNTAFNTBHRH1PTAFR | |
| SCHEMBL29413038 | 0.75 | HRH1 (0.60) | LMNAFNTAFNTBHRH1PTAFR | |
| SCHEMBL21971002 | 0.73 | LMNA (0.46) | LMNASMN1; SMN2FNTAFNTBHRH1 | |
| SCHEMBL6998860 | 0.72 | FNTA (0.49) | LMNAFNTAFNTBHRH1PTAFR | |
| SCHEMBL6996504 | 0.71 | FNTA (0.51) | LMNAFNTAFNTBHRH1PTAFR | |
| SCHEMBL29431445 | 0.71 | ADAM17 (0.48) | LMNASMN1; SMN2HRH1 | |
| SCHEMBL12573365 | 0.71 | ADAM17 (0.48) | LMNASMN1; SMN2HRH1 | |
| SCHEMBL6999299 | 0.70 | FNTA (0.52) | LMNAFNTAFNTBHRH1PTAFR | |
| SCHEMBL6994178 | 0.69 | FNTA (0.56) | LMNASMN1; SMN2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |
| EP-1021448-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998015556-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 1998-04-16 | — | — | WO | disclosed |