Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14415965 | 0.76 | S100A4 (0.41) | LMNASMN1; SMN2S100A4CDC25BNSD2 | |
| SCHEMBL7001329 | 0.75 | LMNA (0.54) | LMNASMN1; SMN2 | |
| SCHEMBL29431445 | 0.72 | ADAM17 (0.48) | LMNASMN1; SMN2S100A4CDC25BNSD2 | |
| SCHEMBL12573365 | 0.72 | ADAM17 (0.48) | LMNASMN1; SMN2S100A4CDC25BNSD2 | |
| SCHEMBL14996503 | 0.69 | PARP1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL11732984 | 0.68 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2TIPARP | |
| SCHEMBL23085038 | 0.64 | CHRM2 (0.46) | LMNASMN1; SMN2 | |
| SCHEMBL30663589 | 0.64 | LMNA (0.41) | LMNASMN1; SMN2S100A4CDC25B | |
| SCHEMBL754994 | 0.64 | CES1 (0.50) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL26711480 | 0.63 | LMNA (0.38) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |