Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5724792 | 0.84 | MIF (0.41) | TRPA1TRPV1MIF | |
| SCHEMBL5724796 | 0.84 | MIF (0.41) | TRPA1TRPV1MIF | |
| SCHEMBL5118852 | 0.82 | ALDH1A1 (0.37) | TRPA1ALDH1A1HSD17B10LMNAALOX15 | |
| SCHEMBL13525512 | 0.79 | METAP2 (0.40) | TRPA1 | |
| SCHEMBL1457221 | 0.78 | TRPA1 (0.41) | TRPA1TRPV1ALDH1A1HSD17B10LMNA | |
| SCHEMBL25333337 | 0.77 | — | — | |
| SCHEMBL27782638 | 0.77 | — | — | |
| SCHEMBL21319577 | 0.77 | NAAA (0.41) | TRPA1ALDH1A1LMNAMIF | |
| SCHEMBL14411072 | 0.74 | NAAA (0.32) | — | |
| SCHEMBL28990108 | 0.74 | TRPA1 (0.31) | TRPA1TRPV1ALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149106-B1 | 4,5-AZOLO-OXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-03-19 | — | — | EP | disclosed |
| EP-1149106-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6197804-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-06 | — | — | US | disclosed |
| US-6153634-A | FOR THERAPY AND PROPHYLAXIS OF CANCER TUMORS; INHIBITOR OFCYCLIN-DEPENDENT KINASES (CDKS) | HOFFMANN-LA ROCHE INC. (US) | 2000-11-28 | — | — | US | disclosed |
| WO-2000035920-A2 | 4,5-AZOLO-OXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |