Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994153 | 0.90 | GAA (0.58) | GAAPKMEGFRNPC1RAB9A | |
| SCHEMBL6948812 | 0.85 | PKM (0.58) | GAAALDH1A1PKMAXLNUDT1 | |
| SCHEMBL4361327 | 0.85 | DDAH1 (0.55) | GAAALDH1A1PKMAXLNUDT1 | |
| SCHEMBL4333658 | 0.85 | ALDH1A1 (0.38) | ALDH1A1CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL4347806 | 0.85 | RIPK1 (0.43) | GAAALDH1A1AXLNUDT1KMT2A | |
| SCHEMBL2972100 | 0.85 | ALDH1A1 (0.38) | ALDH1A1CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL5264712 | 0.85 | ALDH1A1 (0.38) | ALDH1A1CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL18291869 | 0.85 | ALDH1A1 (0.38) | ALDH1A1CCNB2CDK1CCNB1GSK3B | |
| SCHEMBL8288254 | 0.85 | MAPT (0.40) | ALDH1A1CCNB2CDK1CCNB1GSK3B | |
| Hydrochloric Acid SCHEMBL4472373 | 0.83 | PKM (0.37) | ALDH1A1CCNB2CDK1CCNB1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | claimed |
| EP-1189889-B1 | COMPOSITIONS AND METHODS FOR INHIBITING CELL DEATH | ELAN PHARMA INT LTD (IE) | 2003-12-17 | — | — | EP | disclosed |
| US-6541486-B1 | Used for treating ischemia, such as results from stroke or myocardial infarction, trauma, neurodegeneration, and inflammation. | ELAN PHARMA INTERNATIONAL LTD. (IE) | 2003-04-01 | — | — | US | disclosed |