Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995484 | 0.94 | MAPK14 (0.37) | MAPK14MAPTNPSR1TP53STAT3 | |
| SCHEMBL6997171 | 0.75 | MAPT (0.42) | MAPTSTAT3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL20189238 | 0.74 | MEN1 (0.43) | MAPK14MAPTNPSR1TP53STAT3 | |
| SCHEMBL6998703 | 0.73 | CES1 (0.44) | MAPK14MAPTSTAT3KDM4EALDH1A1 | |
| SCHEMBL7001907 | 0.72 | S100A4 (0.49) | MAPTALDH1A1GAAL3MBTL1POLB | |
| SCHEMBL6992698 | 0.71 | CES1 (0.46) | MAPK14MAPTNPSR1TP53STAT3 | |
| SCHEMBL10037461 | 0.71 | MAOA (0.56) | MAPTTP53STAT3KDM4EALDH1A1 | |
| SCHEMBL20187695 | 0.71 | MAPT (0.47) | MAPK14MAPTNPSR1STAT3KDM4E | |
| SCHEMBL6000950 | 0.70 | STAT3 (0.46) | MAPK14MAPTSTAT3KDM4EALDH1A1 | |
| SCHEMBL20187634 | 0.68 | ALDH1A1 (0.54) | MAPTTP53STAT3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093456-B1 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2003-12-17 | — | — | EP | disclosed |
| US-6337346-B1 | BENZODITHIOPHENE DERIVATIVES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-01-08 | — | — | US | disclosed |
| EP-1093456-A2 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-04-25 | — | — | EP | disclosed |
| US-6174913-B1 | TREATING TUMOR BY ADMINISTERING COMPOUNDS E.G.:2-ACETYL-NAPHTHO(2,3-B)THIOPHENE-4,9-DIONE; 2,7-DIACETYL-NAPHTHO(2,3-B)THIOPHENE-4,9-DIONE | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-16 | — | — | US | disclosed |
| WO-1999062909-A9 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIV NORTH CAROLINA (US) | 2000-04-27 | — | — | WO | disclosed |
| WO-1999062909-A2 | NAPHTHO- AND DIHYDROBENZO-THIOPHENE DERIVATIVES AS CYTOTOXIC ANTITUMOR AGENTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-12-09 | — | — | WO | disclosed |