Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 10/20 | 0.41 |
| ▸ | BPTF | Q12830 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006298 | 0.89 | ALDH1A1 (0.46) | BPTFMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7001264 | 0.87 | KAT2B (0.47) | BPTFMEN1KMT2AMAPTNPC1 | |
| SCHEMBL6999530 | 0.77 | KAT2B (0.48) | BPTFMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7001314 | 0.73 | RAB9A (0.52) | NPBWR1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL9674153 | 0.73 | NPBWR1 (0.58) | NPBWR1MEN1KMT2AMAPTTSHR | |
| SCHEMBL6999341 | 0.71 | MAPT (0.42) | NPBWR1BPTFMEN1KMT2AMAPT | |
| SCHEMBL7014865 | 0.71 | KMT2A (0.39) | MEN1KMT2AMAPTTSHRMAPK1 | |
| SCHEMBL11728096 | 0.68 | CNR1 (0.47) | MEN1KMT2AMAPTTSHRMAPK1 | |
| SCHEMBL7003258 | 0.67 | NPC1 (0.45) | MEN1KMT2AMAPTTSHRMAPK1 | |
| SCHEMBL7003256 | 0.67 | NPC1 (0.45) | MEN1KMT2AMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602865-B1 | Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds | IVAX DRUG RESEARCH INSTITUTE, LTD. (HU) | 2003-08-05 | — | — | US | disclosed |
| EP-1129097-B1 | NOVEL TYPE CONDENSED PYRIDAZINONE COMPOUNDS | GYOGYSZERKUTATO INTEZET (HU) | 2003-01-29 | — | — | EP | disclosed |
| EP-1129097-A1 | NOVEL TYPE CONDENSED PYRIDAZINONE COMPOUNDS | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027851-A1 | NOVEL TYPE CONDENSED PYRIDAZINONE COMPOUNDS | Gyógyszerkutató Intézet Kft. (HU) | 2000-05-18 | — | — | WO | disclosed |