Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003532 | 0.93 | CDK9 (0.42) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7004329 | 0.92 | CDK9 (0.39) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7001175 | 0.91 | CDK9 (0.39) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7005945 | 0.90 | PRKAB2 (0.39) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7005986 | 0.84 | PIK3CG (0.36) | CDK9CDK2PIK3CGCCNT1HSD17B10 | |
| SCHEMBL7004127 | 0.83 | CDK7 (0.37) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7145753 | 0.82 | PIK3CG (0.46) | CDK2PIK3CGKDM4ENPC1RAB9A | |
| SCHEMBL7001680 | 0.81 | CDK9 (0.42) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7000703 | 0.81 | CDK9 (0.41) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL7143929 | 0.81 | CDK9 (0.41) | CDK9CDK7CDK2CDK13CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |