Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.32 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005945 | 0.86 | PRKAB2 (0.39) | PIK3CGCCNT1CDK9KCNN3POLB | |
| SCHEMBL7003349 | 0.84 | CDK9 (0.40) | PIK3CGCCNT1CDK9KCNN3POLB | |
| SCHEMBL6998606 | 0.83 | PDE4A (0.39) | PIK3CGPOLBPDE4AUBE2MDCUN1D1 | |
| SCHEMBL7145753 | 0.83 | PIK3CG (0.46) | PIK3CGKCNN3POLBALDH1A1HSD17B10 | |
| SCHEMBL7003532 | 0.82 | CDK9 (0.42) | PIK3CGCCNT1CDK9KCNN3POLB | |
| SCHEMBL7004329 | 0.81 | CDK9 (0.39) | PIK3CGCCNT1CDK9KCNN3POLB | |
| SCHEMBL7001175 | 0.80 | CDK9 (0.39) | PIK3CGCCNT1CDK9KCNN3POLB | |
| SCHEMBL7001263 | 0.79 | PIM1 (0.43) | PIK3CGKCNN3ALDH1A1KCNN1KCNN2 | |
| SCHEMBL6999100 | 0.79 | PIK3CG (0.42) | PIK3CGCCNT1CDK9KCNN3 | |
| SCHEMBL21212282 | 0.76 | PDE2A (0.41) | PIK3CGCCNT1CDK9KCNN3PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |