Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999100 | 0.86 | PIK3CG (0.42) | PIK3CGKCNN3NPC1ADORA1ADORA3 | |
| SCHEMBL7001263 | 0.84 | PIM1 (0.43) | PIK3CGMAPK8KCNN3ALDH1A1KDM4E | |
| SCHEMBL7002738 | 0.84 | KDM4E (0.43) | PIK3CGCCNE1CDK2ALDH1A1KDM4E | |
| SCHEMBL7005986 | 0.83 | PIK3CG (0.36) | PIK3CGCCNE1CDK2KCNN3POLB | |
| SCHEMBL7003349 | 0.82 | CDK9 (0.40) | PIK3CGCCNE1CDK2KCNN3POLB | |
| SCHEMBL7005945 | 0.82 | PRKAB2 (0.39) | PIK3CGCCNE1CDK2KCNN3POLB | |
| SCHEMBL7003532 | 0.81 | CDK9 (0.42) | PIK3CGCCNE1CDK2KCNN3POLB | |
| SCHEMBL7004329 | 0.80 | CDK9 (0.39) | PIK3CGCCNE1CDK2KCNN3POLB | |
| SCHEMBL14492447 | 0.72 | CDK2 (0.48) | PIK3CGCCNE1CDK2HTR1DHTR3A | |
| SCHEMBL7093391 | 0.71 | PIK3CG (0.45) | PIK3CGCCNE1CDK2HTR1DHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1081149-B1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6372749-B1 | PHARMACOLOGICAL EFFECTS SUCH AS ANALGESIC ACTION, INHIBITORY EFFECT ON NITROGEN MONOXIDE SYNTHETASE AND THE LIKE AND ARE USEFUL AS ANALGESICS. | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2002-04-16 | — | — | US | disclosed |
| EP-1081149-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-03-07 | — | — | EP | disclosed |