Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 10/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003397 | 0.92 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6999780 | 0.83 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7003157 | 0.77 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6999772 | 0.77 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6995318 | 0.70 | GABRG2 (0.33) | GABRG2GABRB3GABRA5 | |
| SCHEMBL6996242 | 0.69 | GABRA1 (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7005499 | 0.69 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7002972 | 0.67 | HPGD (0.36) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7001541 | 0.67 | LRRK2 (0.32) | GABRG2GABRB3GABRA5 | |
| SCHEMBL6994216 | 0.65 | GABRA1 (0.37) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |