Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003231 | 0.89 | SLC6A5 (0.38) | SLC6A5KDM4EALDH1A1 | |
| SCHEMBL7005350 | 0.86 | SLC6A5 (0.38) | SLC6A5MAPTSIRT3SIRT5KDM4E | |
| SCHEMBL7564220 | 0.85 | MAPT (0.38) | MAPTSIRT3SIRT5KDM4EMEN1 | |
| SCHEMBL7006166 | 0.84 | ESR1 (0.38) | ALDH1A1 | |
| SCHEMBL7555960 | 0.82 | TDP1 (0.38) | MAPTKDM4EALDH1A1TNF | |
| SCHEMBL7006171 | 0.77 | ESR1 (0.34) | SLC6A5MEN1ALDH1A1KMT2AGAA | |
| SCHEMBL7001088 | 0.77 | NPC1 (0.36) | MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL7007505 | 0.74 | SLC6A5 (0.37) | SLC6A5KDM4EALDH1A1KMT2AGAA | |
| SCHEMBL7556201 | 0.74 | MAPT (0.38) | MAPTSIRT3SIRT5KDM4EMEN1 | |
| SCHEMBL5238999 | 0.72 | TNF (0.40) | SLC6A5MEN1ALDH1A1KMT2ATNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A9 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |