Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 3/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007505 | 0.89 | SLC6A5 (0.37) | SLC6A5ALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL7004077 | 0.86 | SLC6A5 (0.38) | SLC6A5MAPTALDH1A1KMT2AGAA | |
| SCHEMBL7556201 | 0.85 | MAPT (0.38) | MAPTALDH1A1KMT2AGAATSHR | |
| SCHEMBL7554918 | 0.80 | SLC6A5 (0.39) | SLC6A5 | |
| SCHEMBL7006171 | 0.77 | ESR1 (0.34) | SLC6A5ALDH1A1KMT2ALMNAGAA | |
| SCHEMBL7006166 | 0.76 | ESR1 (0.38) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7001088 | 0.75 | NPC1 (0.36) | MAPTALDH1A1KMT2ALMNATSHR | |
| SCHEMBL7003231 | 0.75 | SLC6A5 (0.38) | SLC6A5ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7564220 | 0.74 | MAPT (0.38) | MAPTALDH1A1KMT2AGAATSHR | |
| SCHEMBL7555960 | 0.74 | TDP1 (0.38) | MAPTALDH1A1LMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |