Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009177 | 0.90 | HTR1A (0.42) | HTR1ADRD2DRD3MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7004253 | 0.89 | HTR1A (0.42) | PARP1HTR1ADRD2DRD3CCNE2 | |
| SCHEMBL7004740 | 0.88 | CHRM4 (0.46) | PARP1PARP2 | |
| SCHEMBL7008105 | 0.85 | MTNR1A (0.50) | HTR1ADRD2DRD3MTNR1AMTNR1B | |
| SCHEMBL7006541 | 0.79 | DRD2 (0.42) | PARP1HTR1ADRD2DRD3MTNR1A | |
| SCHEMBL7009570 | 0.78 | ROCK2 (0.42) | HTR1AMTNR1AMTNR1BCCNE2CDK4 | |
| SCHEMBL7004878 | 0.78 | USP30 (0.42) | PARP1HTR1ADRD2DRD3NAMPT | |
| SCHEMBL7003217 | 0.77 | DRD2 (0.41) | HTR1ADRD2DRD3NAMPT | |
| SCHEMBL7004557 | 0.77 | CDK4 (0.53) | HTR1ADRD2DRD3CCNE2CDK4 | |
| SCHEMBL7005191 | 0.76 | PARP1 (0.42) | PARP1HTR1ADRD2DRD3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| EP-1288216-A1 | TRICYCLIC QUINAZOLINEDIONES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105118-A1 | Tricyclic quinazolinediones | PARP1, PARP11, PARP2 | PARP1 1/4885HTR1A 135/4885DRD2 1008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.