Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001371 | 0.80 | BRD4 (0.45) | BRD4CHEK1CDK5CDK5R1PARP1 | |
| SCHEMBL7002739 | 0.80 | GRIA1 (0.39) | BRD4PARP1KDM4EDAOHTR2A | |
| SCHEMBL7005550 | 0.80 | CHEK1 (0.45) | BRD4CHEK1KDM4EALDH1A1KMT2A | |
| SCHEMBL7006748 | 0.80 | BRD4 (0.45) | BRD4CHEK1CDK5TYMSAURKA | |
| SCHEMBL7005666 | 0.78 | DAO (0.41) | BRD4PARP1ALDH1A1DAOLMNA | |
| SCHEMBL4751214 | 0.77 | PARP1 (0.41) | BRD4CHEK1GAAPARP1KDM4E | |
| SCHEMBL7004919 | 0.76 | MEN1 (0.42) | BRD4NPSR1KDM4EMEN1ALDH1A1 | |
| SCHEMBL7006207 | 0.75 | GRIA1 (0.41) | ALOX15PARP1CA12CA9TDP1 | |
| SCHEMBL7007056 | 0.73 | CES1 (0.38) | KDM4EDAOL3MBTL1TDP2 | |
| SCHEMBL7003213 | 0.72 | NSD2 (0.50) | CHEK1MEN1KMT2ACA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |