Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 3/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001371 | 0.80 | BRD4 (0.45) | CHEK1ALDH1A1KDM4ECYP1A2BRD4 | |
| SCHEMBL7006748 | 0.80 | BRD4 (0.45) | CHEK1BRD4AHR | |
| SCHEMBL7002739 | 0.80 | GRIA1 (0.39) | KDM4EBRD4AHRDAOHTR2A | |
| SCHEMBL7005666 | 0.78 | DAO (0.41) | ALDH1A1CYP1A2BRD4DAO | |
| SCHEMBL4751214 | 0.77 | PARP1 (0.41) | CHEK1ALDH1A1KDM4EHPGDBRD4 | |
| SCHEMBL7004919 | 0.76 | MEN1 (0.42) | ALDH1A1KDM4ECYP1A2HPGDBRD4 | |
| SCHEMBL7006207 | 0.75 | GRIA1 (0.41) | CYP1A2DAO | |
| SCHEMBL7007056 | 0.73 | CES1 (0.38) | KDM4ETDP2DAO | |
| SCHEMBL7003383 | 0.72 | TDP2 (0.39) | BRD4TDP2DAOPTPN1HTR2A | |
| SCHEMBL7003213 | 0.69 | NSD2 (0.50) | CHEK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |