Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.51 |
| ▸ | MMP13 | P45452 | 14/20 | 0.51 |
| ▸ | MMP9 | P14780 | 12/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012429 | 0.87 | MMP1 (0.68) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7423599 | 0.85 | MMP1 (0.55) | MMP1MMP13MMP9ADAM17TP53 | |
| SCHEMBL6289470 | 0.82 | MMP1 (0.53) | MMP1MMP13MMP9ADAM17TP53 | |
| SCHEMBL7009850 | 0.81 | MMP9 (0.76) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7008346 | 0.78 | MMP13 (0.78) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7007184 | 0.78 | MMP1 (0.62) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7005027 | 0.76 | MMP1 (0.76) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7013036 | 0.76 | MMP1 (0.64) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL7006362 | 0.76 | MMP1 (0.53) | MMP1MMP13MMP9ADAM17KEAP1 | |
| SCHEMBL6293228 | 0.75 | MMP1 (0.49) | MMP1MMP13MMP9ADAM17TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021413-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | WYETH CORP (US) | 2003-06-11 | — | — | EP | claimed |