Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | AIP | O00170 | 1/20 | 0.55 |
| ▸ | SGTA | O43765 | 1/20 | 0.55 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.55 |
| ▸ | STIP1 | P31948 | 1/20 | 0.55 |
| ▸ | PPP5C | P53041 | 1/20 | 0.55 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.55 |
| ▸ | PPID | Q08752 | 1/20 | 0.55 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.55 |
| ▸ | FKBP8 | Q14318 | 1/20 | 0.55 |
| ▸ | TOMM34 | Q15785 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996786 | 0.80 | FLT3 (0.70) | L3MBTL1ALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL34468610 | 0.77 | TP53 (0.67) | ALDH1A1HSD17B10MAPTHPGDSMN1; SMN2 | |
| SCHEMBL4140802 | 0.75 | KMT2A (0.56) | ALDH1A1HSD17B10MAPTHPGDRAB9A | |
| SCHEMBL7002672 | 0.73 | FLT3 (1.00) | L3MBTL1ALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL24803898 | 0.73 | RAB9A (1.00) | ALDH1A1HSD17B10MAPTRAB9ANPC1 | |
| SCHEMBL31239080 | 0.73 | NPC1 (0.70) | ALDH1A1HSD17B10MAPTRAB9ANPC1 | |
| SCHEMBL11874801 | 0.72 | HSD17B10 (0.71) | ALDH1A1HSD17B10MAPTHPGDRAB9A | |
| SCHEMBL8288732 | 0.71 | POLB (0.78) | ALDH1A1HSD17B10MAPTHPGDRAB9A | |
| SCHEMBL7003055 | 0.71 | AIP (0.74) | L3MBTL1ALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL6997315 | 0.71 | ALDH1A1 (0.60) | L3MBTL1ALDH1A1HSD17B10MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294707-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-03-26 | — | — | EP | claimed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | claimed |
| WO-2001098290-A2 | THIOPHENE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2001-12-27 | — | — | WO | claimed |