Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288732 | 0.86 | POLB (0.78) | TP53SMN1; SMN2MAPTKDM4ETHRB | |
| SCHEMBL13438093 | 0.86 | MAPT (0.64) | TP53SMN1; SMN2MAPTKDM4ETHRB | |
| SCHEMBL34468585 | 0.83 | TNKS2 (0.67) | TP53SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL34468641 | 0.82 | MAPT (0.84) | TP53MAPTKDM4ETHRBALDH1A1 | |
| SCHEMBL34468614 | 0.81 | ALDH1A1 (0.79) | TP53SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL8288727 | 0.81 | MAPT (0.64) | TP53SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL8289729 | 0.81 | MAPT (0.67) | TP53SMN1; SMN2MAPTKDM4ERXFP1 | |
| SCHEMBL34468504 | 0.81 | ALDH1A1 (0.66) | TP53SMN1; SMN2MAPTKDM4ETHRB | |
| SCHEMBL34468566 | 0.79 | ALDH1A1 (0.69) | TP53MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL34468532 | 0.77 | KDM4E (0.58) | TP53MAPTKDM4ETHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260116872-A1 | THIOPHENE BASED APYRASE INHIBITORS | TEXAS CROP SCIENCE INC (US) | 2026-04-30 | — | — | US | claimed |
| US-20260116872-A1 | THIOPHENE BASED APYRASE INHIBITORS | TEXAS CROP SCIENCE INC (US) | 2026-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260116872-A1 | THIOPHENE BASED APYRASE INHIBITORS | SRR, APEH, OSR1 | TP53 3356/4885SMN1; SMN2 4257/4885MAPT 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.