Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 11/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.50 |
| ▸ | FLT3 | P36888 | 6/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.49 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431034 | 0.84 | KDR (0.72) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL6324202 | 0.80 | FLT3 (0.60) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL6324208 | 0.80 | FLT3 (0.60) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL7094064 | 0.80 | DGAT2 (0.43) | KDRPDGFRBEGFRPDGFRAFGFR1 | |
| SCHEMBL7094200 | 0.79 | ALK (0.39) | KDRPDGFRBFLT3AURKBEGFR | |
| SCHEMBL7010602 | 0.79 | KDR (0.43) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL6402187 | 0.79 | KDR (0.63) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL6402191 | 0.79 | KDR (0.63) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL6321383 | 0.77 | FLT3 (0.55) | LRRK2KDRPDGFRBFLT3AURKB | |
| SCHEMBL6321388 | 0.77 | FLT3 (0.55) | LRRK2KDRPDGFRBFLT3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |