Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 8/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.40 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094200 | 0.93 | ALK (0.39) | KDRPDGFRBFGFR1ALKEGFR | |
| SCHEMBL7094064 | 0.90 | DGAT2 (0.43) | KDRPDGFRBFGFR1ALKEGFR | |
| SCHEMBL6321854 | 0.79 | ALK (0.48) | KDRPDGFRBFGFR1ALKPDGFRA | |
| SCHEMBL6321849 | 0.79 | ALK (0.48) | KDRPDGFRBFGFR1ALKPDGFRA | |
| SCHEMBL7006025 | 0.79 | LRRK2 (0.52) | KDRPDGFRBFGFR1ALKEGFR | |
| SCHEMBL7095986 | 0.78 | CHEK1 (0.50) | KDRPDGFRBFGFR1ALKTLK2 | |
| SCHEMBL7004752 | 0.77 | PDGFRB (0.53) | KDRPDGFRBFGFR1TLK2LCK | |
| SCHEMBL6326926 | 0.77 | PDGFRB (0.49) | KDRPDGFRBFGFR1EGFRPDGFRA | |
| SCHEMBL6324172 | 0.76 | SMYD2 (0.47) | KDRPDGFRBFGFR1ALKTLK2 | |
| SCHEMBL6321944 | 0.76 | ALK (0.42) | KDRPDGFRBFGFR1ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |