Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 9/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7010602 | 0.90 | KDR (0.43) | RETALKABL1PDGFRBKDR | |
| SCHEMBL7094200 | 0.89 | ALK (0.39) | RETALKABL1PDGFRBKDR | |
| SCHEMBL6322112 | 0.81 | RET (0.52) | RETALKABL1PDGFRBKDR | |
| SCHEMBL6322108 | 0.81 | RET (0.52) | RETALKABL1PDGFRBKDR | |
| SCHEMBL7006025 | 0.80 | LRRK2 (0.52) | RETALKABL1PDGFRBKDR | |
| SCHEMBL7004752 | 0.78 | PDGFRB (0.53) | PDGFRBKDRFGFR1CHEK1 | |
| SCHEMBL7095986 | 0.75 | CHEK1 (0.50) | ALKPDGFRBKDRFGFR1CHEK1 | |
| SCHEMBL7097437 | 0.73 | KDR (0.70) | RETALKABL1PDGFRBKDR | |
| SCHEMBL6324172 | 0.73 | SMYD2 (0.47) | ALKPDGFRBKDRFGFR1CHEK1 | |
| SCHEMBL6326926 | 0.72 | PDGFRB (0.49) | PDGFRBKDRFGFR1EGFRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |