Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013150 | 0.93 | KMT2A (0.40) | KMT2AMEN1KCNK3ALDH1A1HPGD | |
| SCHEMBL7006701 | 0.86 | ALOX5 (0.41) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL7009127 | 0.85 | SMN1; SMN2 (0.38) | ALDH1A1HPGDNPSR1MAPTGAA | |
| SCHEMBL6294039 | 0.85 | ALDH1A1 (0.47) | KMT2AMEN1KCNK3ALDH1A1HPGD | |
| SCHEMBL6294501 | 0.83 | KCNK3 (0.48) | KMT2AMEN1KCNK3ALDH1A1HPGD | |
| SCHEMBL7012237 | 0.83 | RIPK3 (0.45) | KMT2A | |
| SCHEMBL7008536 | 0.83 | RIPK3 (0.45) | KMT2A | |
| SCHEMBL7006189 | 0.80 | RIPK3 (0.44) | KMT2A | |
| SCHEMBL7011496 | 0.78 | NPSR1 (0.38) | ALDH1A1HPGDNPSR1MAPTGAA | |
| SCHEMBL7010615 | 0.77 | MAPK14 (0.44) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252163-B1 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2003-09-24 | — | — | EP | disclosed |