Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006366 | 0.86 | KMT2A (0.38) | ALOX5KMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL6290812 | 0.84 | KMT2A (0.44) | ALOX5KMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL7013150 | 0.78 | KMT2A (0.40) | ALOX5KMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL6294039 | 0.78 | ALDH1A1 (0.47) | KMT2AMEN1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6294501 | 0.76 | KCNK3 (0.48) | KMT2AMEN1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL27490983 | 0.73 | ALOX5 (0.36) | ALOX5 | |
| SCHEMBL7009127 | 0.71 | SMN1; SMN2 (0.38) | ALOX5KDM4EHSD17B10ALDH1A1HTT | |
| SCHEMBL7012237 | 0.67 | RIPK3 (0.45) | KMT2A | |
| SCHEMBL7008536 | 0.67 | RIPK3 (0.45) | KMT2A | |
| SCHEMBL6294518 | 0.66 | GABRA1 (0.41) | ALOX5KMT2AMEN1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252163-B1 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2003-09-24 | — | — | EP | disclosed |