Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007079 | 0.89 | HPGD (0.51) | CCR2HPGDHSD17B10TNFRSF1AMTNR1B | |
| SCHEMBL7097677 | 0.86 | HPGD (0.52) | CCR2HPGDHSD17B10TNFRSF1AMTNR1B | |
| SCHEMBL699964 | 0.84 | CCR2 (0.65) | CCR2HPGDHSD17B10MTNR1BMTNR1A | |
| SCHEMBL30622480 | 0.81 | CCR2 (0.61) | CCR2HPGDHSD17B10MTNR1BMTNR1A | |
| SCHEMBL7688469 | 0.77 | CCR2 (0.56) | CCR2HPGDHSD17B10MTNR1BMTNR1A | |
| SCHEMBL3963296 | 0.77 | CCR2 (0.72) | CCR2HPGDMTNR1BMTNR1AKDM4E | |
| SCHEMBL2326863 | 0.76 | CCR2 (0.55) | CCR2HPGDHSD17B10MTNR1BMTNR1A | |
| SCHEMBL3963968 | 0.76 | CCR2 (0.67) | CCR2MTNR1BMTNR1AF10 | |
| SCHEMBL3277800 | 0.76 | CCR2 (0.61) | CCR2HPGDHSD17B10MTNR1BMTNR1A | |
| SCHEMBL30547718 | 0.75 | CCR2 (0.54) | CCR2HPGDHSD17B10TNFRSF1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |
| EP-1200439-A1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | Novuspharma S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009136-A1 | 1,2-DIHYDRO-1-OXO-PYRAZINO[1,2-A]INDOLE DERIVATIVES | NOVUSPHARMA S.P.A. (IT) | 2001-02-08 | — | — | WO | disclosed |