Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007079 | 0.88 | HPGD (0.51) | HPGDHSD17B10TNFRSF1ACCR2F10 | |
| SCHEMBL7006463 | 0.86 | CCR2 (0.60) | HPGDHSD17B10TNFRSF1ACCR2F10 | |
| SCHEMBL2272984 | 0.78 | KDM4E (0.51) | HPGDHSD17B10CCR2KMT2ATSHR | |
| SCHEMBL699964 | 0.70 | CCR2 (0.65) | HPGDHSD17B10CCR2MEN1KMT2A | |
| SCHEMBL30622480 | 0.70 | CCR2 (0.61) | HPGDHSD17B10CCR2F10MTNR1B | |
| SCHEMBL31008782 | 0.69 | CCR2 (0.51) | HPGDHSD17B10CCR2F10MEN1 | |
| SCHEMBL6720270 | 0.68 | HPGD (1.00) | HPGDHSD17B10MEN1KMT2ATSHR | |
| SCHEMBL6775247 | 0.68 | CCR2 (0.65) | CCR2F10KMT2AMTNR1BMTNR1A | |
| SCHEMBL5622779 | 0.68 | CCR2 (0.47) | HPGDHSD17B10CCR2F10MEN1 | |
| SCHEMBL2276664 | 0.67 | L3MBTL1 (0.52) | HPGDHSD17B10CCR2MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200439-B1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | NOVUSPHARMA SPA (IT) | 2003-06-25 | — | — | EP | disclosed |
| EP-1200439-A1 | 1,2-DIHYDRO-1-OXO-PARAZINO(1,2-A) INDOLE DERIVATIVES | Novuspharma S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009136-A1 | 1,2-DIHYDRO-1-OXO-PYRAZINO[1,2-A]INDOLE DERIVATIVES | NOVUSPHARMA S.P.A. (IT) | 2001-02-08 | — | — | WO | disclosed |