Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 6/20 | 0.44 |
| ▸ | ATP4A | P20648 | 2/20 | 0.43 |
| ▸ | ATP4B | P51164 | 2/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013840 | 0.86 | PLA2G1B (0.47) | PLA2G1BATP4AATP4BPTGER1 | |
| SCHEMBL7014844 | 0.85 | ATM (0.48) | PLA2G1BATP4AATP4BPTGER1ALDH1A1 | |
| SCHEMBL7005971 | 0.85 | MRGPRX4 (0.45) | PLA2G1BATP4AATP4BALDH1A1CYP1A2 | |
| SCHEMBL8320616 | 0.85 | MRGPRX4 (0.45) | PLA2G1BATP4AATP4BPTGER1 | |
| SCHEMBL7006186 | 0.83 | PLA2G1B (0.48) | PLA2G1BATP4AATP4BFOLH1CYP1A2 | |
| SCHEMBL7011597 | 0.82 | ATP4A (0.44) | PLA2G1BATP4AATP4BCYP1A2CYP3A4 | |
| SCHEMBL7016240 | 0.82 | ATM (0.44) | PLA2G1BATP4AATP4BPTGER1 | |
| SCHEMBL7013814 | 0.81 | ATP4A (0.42) | PLA2G1BATP4AATP4BPTGER1ALDH1A1 | |
| SCHEMBL7011444 | 0.80 | ATP4A (0.43) | PLA2G1BATP4AATP4BCYP1A2CYP3A4 | |
| SCHEMBL7006665 | 0.79 | PLA2G1B (0.43) | PLA2G1BATP4AATP4BPTGER1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |