Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.43 |
| ▸ | ATP4B | P51164 | 3/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014844 | 0.89 | ATM (0.48) | ATP4AATP4BPLA2G1BATMHPGD | |
| SCHEMBL7016240 | 0.87 | ATM (0.44) | ATP4AATP4BPLA2G1BATMHPGD | |
| SCHEMBL7005845 | 0.86 | ABCB1 (0.47) | ATP4AATP4BPLA2G1BATMKMT2A | |
| SCHEMBL7006665 | 0.82 | PLA2G1B (0.43) | ATP4AATP4BPLA2G1BATMHPGD | |
| SCHEMBL7005971 | 0.82 | MRGPRX4 (0.45) | ATP4AATP4BPLA2G1BHPGDCYP1A2 | |
| SCHEMBL9080274 | 0.82 | PLA2G1B (0.45) | PLA2G1BMRGPRX4 | |
| SCHEMBL7014295 | 0.81 | PLA2G1B (0.49) | ATP4AATP4BPLA2G1BCYP1A2CYP3A4 | |
| SCHEMBL7013814 | 0.80 | ATP4A (0.42) | ATP4AATP4BPLA2G1BHPGDCYP1A2 | |
| SCHEMBL7006648 | 0.80 | PLA2G1B (0.44) | ATP4AATP4BPLA2G1BCYP1A2CYP3A4 | |
| SCHEMBL7013840 | 0.79 | PLA2G1B (0.47) | ATP4AATP4BPLA2G1BRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |