Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | RXRG | P48443 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.40 |
| ▸ | ATP4A | P20648 | 3/20 | 0.40 |
| ▸ | ATP4B | P51164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014844 | 0.88 | ATM (0.48) | PLA2G1BRXRARXRBRXRGMRGPRX4 | |
| SCHEMBL9080274 | 0.85 | PLA2G1B (0.45) | PLA2G1BMRGPRX4NR4A2PTGER1 | |
| SCHEMBL7016240 | 0.84 | ATM (0.44) | PLA2G1BRXRARXRBRXRGMRGPRX4 | |
| SCHEMBL7011444 | 0.82 | ATP4A (0.43) | PLA2G1BRXRARXRBRXRGMRGPRX4 | |
| SCHEMBL7005845 | 0.81 | ABCB1 (0.47) | PLA2G1BMRGPRX4ATP4AATP4BMAPT | |
| SCHEMBL7013814 | 0.79 | ATP4A (0.42) | PLA2G1BMRGPRX4ATP4AATP4BMAPT | |
| SCHEMBL7006648 | 0.79 | PLA2G1B (0.44) | PLA2G1BATP4AATP4BMAPTMEN1 | |
| SCHEMBL8320616 | 0.79 | MRGPRX4 (0.45) | PLA2G1BRXRARXRBRXRGMRGPRX4 | |
| SCHEMBL7013840 | 0.78 | PLA2G1B (0.47) | PLA2G1BRXRARXRBRXRGATP4A | |
| SCHEMBL7005971 | 0.78 | MRGPRX4 (0.45) | PLA2G1BMRGPRX4ATP4AATP4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |