Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | ATP4A | P20648 | 1/20 | 0.41 |
| ▸ | ATP4B | P51164 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006648 | 0.85 | PLA2G1B (0.44) | ATP4AATP4BPTGER1PLA2G1B | |
| SCHEMBL7013840 | 0.84 | PLA2G1B (0.47) | RXRARXRBRXRGATP4AATP4B | |
| SCHEMBL7014844 | 0.83 | ATM (0.48) | MRGPRX4RXRARXRBRXRGATP4A | |
| SCHEMBL7005971 | 0.83 | MRGPRX4 (0.45) | MRGPRX4ATP4AATP4BNPC1PLA2G1B | |
| SCHEMBL9080274 | 0.82 | PLA2G1B (0.45) | MRGPRX4PTGER1FFAR4PLA2G1B | |
| SCHEMBL7016240 | 0.79 | ATM (0.44) | MRGPRX4RXRARXRBRXRGATP4A | |
| SCHEMBL7006665 | 0.79 | PLA2G1B (0.43) | MRGPRX4RXRARXRBRXRGATP4A | |
| SCHEMBL7013814 | 0.79 | ATP4A (0.42) | MRGPRX4ATP4AATP4BPTGER1NPC1 | |
| SCHEMBL7011444 | 0.78 | ATP4A (0.43) | MRGPRX4RXRARXRBRXRGATP4A | |
| SCHEMBL7005845 | 0.76 | ABCB1 (0.47) | MRGPRX4ATP4AATP4BPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |