Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2062891 | 0.86 | SMPD1 (0.56) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL5704614 | 0.84 | SIGMAR1 (0.59) | SIGMAR1EBPTMEM97 | |
| SCHEMBL1157301 | 0.82 | PDE4A (0.56) | SIGMAR1CYP19A1PDE4APDE4BPDE4C | |
| SCHEMBL14937721 | 0.82 | MAPT (0.50) | MAPTKDM4EGAAL3MBTL1CYP19A1 | |
| SCHEMBL15814937 | 0.81 | CYP19A1 (0.50) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL30739220 | 0.81 | MAOB (0.43) | MAPTKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL29178849 | 0.81 | MAOB (0.43) | MAPTKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL2748971 | 0.80 | KDM4E (0.60) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL6585913 | 0.80 | FDPS (0.62) | MAPTL3MBTL1TDP1MAPK1 | |
| SCHEMBL2937821 | 0.80 | PDE4A (0.61) | SMPD1HDAC1HDAC8HDAC6PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |