Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A1 | P53985 | 17/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC16A7 | O60669 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008610 | 0.83 | PDE1A (0.41) | SLC16A1CYP2C9CYP3A4L3MBTL1MEN1 | |
| SCHEMBL7004524 | 0.82 | LMNA (0.40) | SLC16A1CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL3833080 | 0.78 | SMN1; SMN2 (0.42) | SLC16A1CYP2C9CYP3A4L3MBTL1MEN1 | |
| SCHEMBL3829773 | 0.77 | SLC16A1 (0.39) | SLC16A1CYP2C9CYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL4803164 | 0.76 | SLC16A1 (0.53) | SLC16A1CYP2C9CYP3A4MEN1ALDH1A1 | |
| SCHEMBL7005642 | 0.76 | SLC16A1 (0.66) | SLC16A1CYP2C9CYP3A4SLC16A7 | |
| SCHEMBL6726548 | 0.75 | PDE1A (0.45) | SLC16A1CYP3A4ALDH1A1 | |
| SCHEMBL7005454 | 0.75 | SLC16A1 (0.65) | SLC16A1CYP2C9CYP3A4SLC16A7 | |
| SCHEMBL7848415 | 0.73 | SLC16A1 (0.60) | SLC16A1CYP2C9CYP3A4SLC16A7 | |
| SCHEMBL5864658 | 0.69 | SLC16A1 (0.75) | SLC16A1CYP2C9CYP3A4SLC16A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |