Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350931 | 0.84 | NOTUM (0.44) | LMNAPOLBALDH1A1ADORA2BADORA1 | |
| SCHEMBL7007619 | 0.82 | SLC16A1 (0.51) | ALDH1A1SLC16A1CYP3A4CYP2C9 | |
| SCHEMBL4801047 | 0.80 | ALDH1A1 (0.40) | LMNAPOLBALDH1A1MAPTCYP3A4 | |
| SCHEMBL7006901 | 0.68 | SLC16A1 (0.59) | SLC16A1CYP3A4CYP2C9 | |
| SCHEMBL7008494 | 0.67 | SLC16A1 (0.52) | SLC16A1CYP3A4CYP2C9 | |
| SCHEMBL7008006 | 0.66 | PARG (0.43) | LMNAPOLBALDH1A1ADORA2BADORA1 | |
| SCHEMBL7008610 | 0.66 | PDE1A (0.41) | LMNAALDH1A1SLC16A1ADORA1CYP3A4 | |
| SCHEMBL4804328 | 0.65 | ADORA2B (0.43) | LMNAALDH1A1ADORA2BMAPTCYP1A2 | |
| SCHEMBL3831387 | 0.64 | ALDH1A1 (0.40) | LMNAALDH1A1ADORA2BMAPTCYP3A4 | |
| SCHEMBL7017390 | 0.61 | DRD2 (0.42) | LMNAPOLBALDH1A1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |