Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | NQO2 | P16083 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8173009 | 1.00 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL7543112 | 0.85 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL9134353 | 0.85 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL353332 | 0.85 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL6134662 | 0.81 | DRD2 (0.57) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL6134658 | 0.81 | DRD2 (0.57) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL3442063 | 0.79 | MTNR1A (0.46) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL355640 | 0.78 | DRD2 (0.58) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL23576279 | 0.78 | MTNR1A (0.45) | MTNR1AMTNR1BACHECA1CA2 | |
| SCHEMBL8040314 | 0.77 | DRD2 (0.39) | DRD2DRD3HTR1DMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988296-B1 | NAPHTHOTHIAZOLONE DERIVATIVES ACTIVE ON THE D 3 DOPAMINERGIC RECEPTOR | ZAMBON SPA (IT) | 2003-01-08 | — | — | EP | disclosed |
| US-6107318-A | PSYCHOLOGICAL DISORDERS | ZAMBON GROUP S.P.A. (IT) | 2000-08-22 | — | — | US | disclosed |