Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | ACHE | P22303 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004613 | 1.00 | DRD2 (0.39) | DRD2HTR1DDRD3MTNR1AMTNR1B | |
| SCHEMBL7007666 | 0.77 | DRD2 (0.62) | DRD2HTR1DDRD3MTNR1AMTNR1B | |
| SCHEMBL8173009 | 0.77 | DRD2 (0.62) | DRD2HTR1DDRD3MTNR1AMTNR1B | |
| SCHEMBL6949943 | 0.68 | RB1 (0.35) | DRD2DRD3MTNR1AMTNR1BCA1 | |
| SCHEMBL6949950 | 0.68 | RB1 (0.35) | DRD2DRD3MTNR1AMTNR1BCA1 | |
| SCHEMBL9134353 | 0.64 | DRD2 (0.62) | DRD2HTR1DDRD3MTNR1AMTNR1B | |
| SCHEMBL353332 | 0.64 | DRD2 (0.62) | DRD2HTR1DDRD3MTNR1AMTNR1B | |
| SCHEMBL7543112 | 0.64 | DRD2 (0.62) | DRD2HTR1DDRD3MTNR1AMTNR1B | |
| SCHEMBL3441770 | 0.63 | PNMT (0.50) | — | |
| SCHEMBL21798809 | 0.63 | MTNR1A (0.49) | MTNR1AMTNR1BCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107318-A | PSYCHOLOGICAL DISORDERS | ZAMBON GROUP S.P.A. (IT) | 2000-08-22 | — | — | US | disclosed |
| EP-0988296-A1 | NAPHTHOTHIAZOLONE DERIVATIVES ACTIVE ON THE D 3 DOPAMINERGIC RECEPTOR | ZAMBON GROUP S.p.A. (IT) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998056778-A1 | NAPHTHOTHIAZOLONE DERIVATIVES ACTIVE ON THE D3 DOPAMINERGIC RECEPTOR | ZAMBON GROUP S.P.A. (IT) | 1998-12-17 | — | — | WO | disclosed |