Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | HTR1D | P28221 | 2/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9134353 | 1.00 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL353332 | 1.00 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL6644445 | 0.91 | DRD2 (0.52) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL8173009 | 0.85 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL7007666 | 0.85 | DRD2 (0.62) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL6053198 | 0.82 | DRD2 (0.46) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL5681677 | 0.82 | MTNR1A (0.53) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL7035289 | 0.82 | MTNR1A (0.53) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL6134662 | 0.82 | DRD2 (0.57) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL6134658 | 0.82 | DRD2 (0.57) | DRD2DRD3HTR1DMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894787-B1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6136852-A | 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0894787-A1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1999-02-03 | — | — | EP | disclosed |
| US-5449813-A | Phenylethanolamino- and phenylethanolaminomethyl-tetralines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-09-12 | — | — | US | disclosed |
| EP-0500443-B1 | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-04-26 | — | — | EP | disclosed |
| US-5401879-A | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-03-28 | — | — | US | disclosed |
| US-5210276-A | PHENYLETHANOLAMINO- AND PHENYLETHANOLAMINOMETHYL-TETRALINES, PROCESS FOR THE PREPARATION THEREOF, INTERMEDIATES IN SAID PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELF SANOFI (FR) | 1993-05-11 | — | — | US | disclosed |
| EP-0500443-A1 | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | SANOFI (FR) | 1992-08-26 | — | — | EP | disclosed |
| EP-0499755-A1 | Phenylethanolaminotetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | MIDY S.p.A. (IT) | 1992-08-26 | — | — | EP | disclosed |