Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.39 |
| ▸ | CTSL | P07711 | 8/20 | 0.36 |
| ▸ | CTSK | P43235 | 5/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005820 | 0.87 | CTSS (0.38) | CTSSCTSLCTSKCTSCCTSB | |
| SCHEMBL6971904 | 0.83 | CTSS (0.52) | CTSSCTSLCTSC | |
| Hydrochloric Acid SCHEMBL5367945 | 0.82 | CTSS (0.51) | CTSSCTSLCTSC | |
| SCHEMBL7011171 | 0.79 | CTSS (0.35) | CTSSCTSLCTSKCTSBCPB2 | |
| SCHEMBL6975626 | 0.79 | CTSS (0.38) | CTSSCTSLCTSKCTSCCTSB | |
| SCHEMBL5363252 | 0.79 | CTSS (0.60) | CTSSCTSLCTSC | |
| SCHEMBL7012870 | 0.72 | CTSS (0.41) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7007018 | 0.72 | CTSL (0.33) | CTSSCTSL | |
| SCHEMBL5363187 | 0.72 | CTSS (0.39) | CTSSCTSLCTSKCTSB | |
| SCHEMBL5364783 | 0.71 | CTSS (0.49) | CTSSCTSLCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322613-A1 | SPIROHETEROCYCLIC NITRILES USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2002020485-A1 | SPIROHETEROCYCLIC NITRILES USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-03-14 | — | — | WO | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |