Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10398766 | 0.88 | ALDH1A1 (0.57) | HPGDLMNAGAACASP3CASP6 | |
| SCHEMBL10398716 | 0.88 | HPGD (0.54) | HPGDLMNAGAACASP3CASP6 | |
| SCHEMBL6772611 | 0.81 | HPGD (0.64) | HPGDLMNAGAACASP3CASP6 | |
| SCHEMBL6329014 | 0.81 | HPGD (0.68) | HPGDGAACASP3CASP6SENP8 | |
| SCHEMBL8819491 | 0.79 | PSEN1 (0.50) | HPGD | |
| SCHEMBL16456324 | 0.75 | HPGD (0.74) | HPGDLMNAGAACASP3CASP6 | |
| SCHEMBL12962502 | 0.75 | LMNA (0.73) | LMNAGAAALDH1A1KMT2ACYP2C9 | |
| SCHEMBL31422646 | 0.74 | HPGD (1.00) | HPGDGAACASP3CASP6SENP8 | |
| SCHEMBL143970 | 0.74 | HPGD (1.00) | HPGDGAACASP3CASP6SENP8 | |
| SCHEMBL22500073 | 0.74 | HPGD (0.58) | HPGDGAACASP3CASP6SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |