Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508548 | 0.83 | LCK (0.53) | POLBALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL6862112 | 0.78 | LCK (0.53) | POLBALDH1A1KDM4EMAPTNPC1 | |
| SCHEMBL7005305 | 0.71 | ALDH1A1 (0.44) | GAAALDH1A1KDM4ELCKKDR | |
| SCHEMBL27336028 | 0.68 | SRC (0.51) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL6250271 | 0.66 | SRC (0.47) | POLBGAAALDH1A1KDM4EMAPT | |
| SCHEMBL7008781 | 0.66 | PLA2G1B (0.40) | POLBGAAALDH1A1KDM4EMAPT | |
| SCHEMBL7009014 | 0.65 | CA12 (0.36) | POLBGAAALDH1A1KDM4EMAPT | |
| SCHEMBL3715556 | 0.65 | CA12 (0.50) | POLBGAAALDH1A1KDM4EMAPT | |
| SCHEMBL18159867 | 0.65 | POLB (0.60) | POLBGAAALDH1A1KDM4EMAPT | |
| SCHEMBL22169508 | 0.65 | POLB (1.00) | POLBGAAALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |