Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008755 | 0.81 | CA1 (0.46) | CA1CA2ACHETACR3ATM | |
| SCHEMBL6365668 | 0.81 | ATM (0.47) | CA1CA2ACHETACR3ATM | |
| SCHEMBL3861479 | 0.74 | DYRK1A (0.39) | PDE1BPLA2G10ALDH1A1 | |
| SCHEMBL2908454 | 0.71 | MTNR1A (0.55) | CA1CA2ACHEATMCTSL | |
| SCHEMBL7009702 | 0.71 | KMO (0.44) | ATMLMNAMAPTCTSLCTSS | |
| SCHEMBL11561410 | 0.70 | NPC1 (0.65) | CA1CA2ACHEATMMAPT | |
| SCHEMBL27783096 | 0.70 | NPC1 (0.65) | CA1CA2ACHEATMMAPT | |
| SCHEMBL1554809 | 0.69 | CA1 (0.58) | CA1CA2ACHEATMLMNA | |
| SCHEMBL4443866 | 0.69 | AOC3 (0.55) | ATMLMNAL3MBTL1TDP1MTNR1A | |
| SCHEMBL9293928 | 0.69 | LMNA (0.59) | LMNAMAPTCTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268438-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070702-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |