Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | PTPRF | P10586 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262646 | 0.84 | CYP1A2 (0.54) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL11024329 | 0.84 | ESR1 (0.69) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL4437809 | 0.84 | POLB (0.58) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL5261202 | 0.83 | KCNJ1 (0.45) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL9069704 | 0.82 | ESR1 (0.61) | — | |
| Ammonia Solution, Strong SCHEMBL8867125 | 0.81 | CYP2D6 (0.52) | KMT2AMEN1SMN1; SMN2CYP1A2CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL8975868 | 0.81 | SMN1; SMN2 (0.53) | KMT2AMEN1NPC1TP53RAB9A | |
| Iodide SCHEMBL5262196 | 0.81 | KCNJ1 (0.44) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL7118574 | 0.80 | CYP1A2 (0.50) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL27864585 | 0.80 | ALDH1A1 (0.62) | KMT2AMEN1CYP1A2CYP2C19CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1267906-A1 | LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001072324-A1 | LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-10-04 | — | — | WO | claimed |