Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.52 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27839140 | 0.84 | NOS2 (0.43) | NOS2NOS3TDP1L3MBTL1CYP3A4 | |
| SCHEMBL7264503 | 0.82 | NOS2 (0.38) | NOS2TDP1L3MBTL1CYP3A4CYP2D6 | |
| SCHEMBL28572387 | 0.81 | NOS2 (0.44) | NOS2NOS3TDP1L3MBTL1CYP3A4 | |
| SCHEMBL8713669 | 0.81 | NOS2 (0.49) | NOS2NOS3TDP1L3MBTL1CYP3A4 | |
| SCHEMBL23987750 | 0.80 | NOS2 (0.61) | NOS2NOS3CYP3A4ALDH1A1KDM4E | |
| SCHEMBL8713672 | 0.78 | NOS2 (0.82) | NOS2NOS3SKP2TLR8 | |
| SCHEMBL19005863 | 0.78 | NOS2 (0.42) | NOS2NOS3TDP1L3MBTL1CYP3A4 | |
| SCHEMBL28129531 | 0.78 | NOS2 (0.50) | NOS2NOS3TDP1L3MBTL1CYP3A4 | |
| SCHEMBL16280467 | 0.78 | NOS2 (0.50) | NOS2NOS3TDP1L3MBTL1CYP3A4 | |
| SCHEMBL31278013 | 0.78 | SMPD3 (0.40) | NOS2CYP3A4CYP2D6KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268502-A1 | O-ARYL GLUCOSIDE SGLT2 INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074834-A1 | O-ARYL GLUCOSIDE SGLT2 INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |