Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.38 |
| ▸ | PDE1A | P54750 | 3/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864669 | 0.85 | PDE1B (0.47) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL5864744 | 0.85 | PDE3B (0.47) | PARGPDE1BPDE1APDE1CPDE2A | |
| SCHEMBL5865280 | 0.82 | ADORA2A (0.44) | PARGSLC16A1ADORA2AADORA1 | |
| SCHEMBL5864716 | 0.81 | PDE1B (0.41) | PDE1BPDE1APDE1CPDE2AALDH1A1 | |
| SCHEMBL5865129 | 0.80 | PARG (0.36) | PARGPDE1BPDE1APDE1CPDE2A | |
| SCHEMBL7008583 | 0.80 | TBXAS1 (0.42) | PARGPDE1BPDE1APDE1CPDE2A | |
| SCHEMBL7011267 | 0.79 | PDE1B (0.39) | PDE1BPDE1APDE1CPDE2ASLC16A1 | |
| SCHEMBL5864838 | 0.79 | ALDH1A1 (0.41) | PARGPDE1BPDE1APDE1CPDE2A | |
| SCHEMBL7010765 | 0.77 | SLC16A1 (0.38) | PDE1BPDE1APDE1CPDE2AALDH1A1 | |
| SCHEMBL5864692 | 0.76 | SLC16A1 (0.56) | SLC16A1CYP2C9MAPKAPK2CAMK2BHIPK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984644-B2 | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | claimed |
| US-6469014-B1 | IMMUNOSUPPRESSIVE ACTIVITY | ASTRAZENECA AB (SE) | 2002-10-22 | — | — | US | claimed |
| EP-0991653-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-16 | — | — | EP | claimed |
| US-6984644-B2 | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | disclosed |
| US-6469014-B1 | IMMUNOSUPPRESSIVE ACTIVITY | ASTRAZENECA AB (SE) | 2002-10-22 | — | — | US | disclosed |