Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 6/20 | 0.41 |
| ▸ | CNR2 | P34972 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641620 | 0.85 | SLC6A2 (0.48) | SLC6A4SLC6A2SLC6A3CYP1A2CYP2D6 | |
| SCHEMBL7005600 | 0.79 | PNMT (0.53) | SLC6A4SLC6A2IDO1TDO2SIGMAR1 | |
| SCHEMBL25343509 | 0.78 | SMO (0.53) | SLC6A4CHRNB2CHRNA4SLC6A2SLC6A3 | |
| SCHEMBL16745473 | 0.78 | FFAR1 (0.45) | SLC6A4SLC6A2SLC6A3SIGMAR1PPARG | |
| SCHEMBL6442526 | 0.76 | SLC6A4 (0.57) | SLC6A4CHRNB2CHRNA4SLC6A2SLC6A3 | |
| SCHEMBL4603704 | 0.76 | SLC6A2 (0.53) | SLC6A4CHRNB2CHRNA4SLC6A2SLC6A3 | |
| SCHEMBL4603712 | 0.76 | SLC6A2 (0.53) | SLC6A4CHRNB2CHRNA4SLC6A2SLC6A3 | |
| SCHEMBL8317452 | 0.76 | ALDH1A1 (0.45) | SLC6A4SLC6A2SLC6A3CNR1CNR2 | |
| Ammonia Solution, Strong SCHEMBL8867131 | 0.74 | SLC6A2 (0.52) | SLC6A4CHRNB2CHRNA4SLC6A2SLC6A3 | |
| SCHEMBL3374924 | 0.74 | SLC6A2 (0.56) | SLC6A4CHRNB2CHRNA4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1267906-A1 | LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001072324-A1 | LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-10-04 | — | — | WO | claimed |