Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355684 | 0.89 | ACE2 (0.67) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL6559603 | 0.84 | PARP10 (0.44) | ACE2BCL2MCL1 | |
| SCHEMBL8643468 | 0.81 | ALDH1A1 (0.48) | KMT2AMEN1TDP1KDM4ELMNA | |
| SCHEMBL2159198 | 0.81 | ACE2 (0.54) | ACE2GRM1KDM4ERXRARXRB | |
| SCHEMBL13816269 | 0.80 | ACE2 (0.61) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL8559784 | 0.80 | PLA2G2D (0.54) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL7898447 | 0.78 | KDM4E (0.52) | ACE2KDM4EAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL5366250 | 0.77 | ACE2 (0.57) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL1356407 | 0.77 | ACE2 (0.67) | ACE2GRM1KMT2AMEN1CYP1A2 | |
| SCHEMBL6935737 | 0.77 | ACE2 (0.57) | ACE2GRM1KMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |